Sana Biotechnology is hiring a

CNS In Vivo Manager

Cambridge, United States

About the role

The CNS In Vivo Manager helps to ensure the smooth operation and cross-project coordination of glial cell transplantation research in Sana's Cambridge CNS lab. More broadly, this multidisciplinary position is intended to dedicate at least 50% effort to bench / wet lab work. Management duties include experimental design and implementation, preclinical transplant coordination, personnel management, coordination of animal husbandry, protocol amendments, and compliance, and assist with inventory and fiscal management within the CNS program.

The wet lab portion of the CNS In Vivo Manager position will support in vivo assessment of human manufactured glial cells transplanted into pre-clinical models. This individual will both manage and help evaluate transplant success into the mouse brain using techniques of murine brain sectioning, fluorescent immunohistochemistry, microscopy, and image analysis within Sana's CNS Cell Therapy lab. This position includes technically diverse bench and analytic work, as well as the training of research staff in techniques and equipment use, across the CNS in vivo program.

The CNS In Vivo Manager will report on a direct basis to the Sr Director, CNS Biology, and work under the broader direction of the Head of CNS Therapy.

What you'll do

  • Neurohistological processing including tissue sectioning and immunohistochemistry of mouse brain tissue following transplantation
  • Managing the daily operations of the CNS Cell Therapy in vivo program as well as contributing to coordination of the CNS platform
  • Assure the quality and integrity of all data collection and documentation
  • Microscopy and image analysis of processed samples
  • Work with in vivo staff to troubleshoot histology protocols
  • Assure compliance with all relevant lab safety and biosafety regulations
  • Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen)

What we're looking for

As a successful candidate, you are expected to have extensive hands-on expertise in the neurohistological methods necessary to assess transplanted animals, particularly tissue sectioning and immunohistochemistry, quantitative histology and microscopy (epifluorescent and confocal). You should also be familiar with concepts of transgenic mouse husbandry and identification of suitable mouse models. You will have sufficient personal expertise to teach as well as troubleshoot these techniques. Also, you are expected to contribute towards the maintenance of both the histology and surgical lab environments, including day to day operations and personnel coordination, as well as assuring the quality of data collection.

  • BS/MS or relevant degree in neuroscience or cell biology, chemistry or biotechnology, or a related field
  • Significant expertise in and understanding of rodent neuroanatomy
  • Experience working in team-based settings and willingness to provide guidance and leadership
  • Significant experience in mouse brain tissue preparation and sectioning
  • Significant experience in immunohistochemistry (IHC), particularly immunofluorescence
  • Experience or willingness to learn microscopy and digital image analysis
  • Experience working with preclinical models.
  • Understanding of mouse colony management, transgenic mouse models, and genotyping
  • Excellent interpersonal, communicative and problem-solving skills
  • Proficiency with MS Office, and with standard programs for statistical analysis (e.g., GraphPad Prism) and image analysis and quantification (ie ImageJ)

What will separate you from the crowd

  • Background in neuroscience/neurobiology
  • Experience in mouse brain tissue sectioning, particularly on the cryostat
  • An interest in management and experience in training others on technical approaches
  • Experience in immunohistochemistry with a focus on immunofluorescence and multiplex antibody labeling of rodent brain tissue sections
  • Experience in rodent handling, brain dissection, and stereotactic surgery
  • Experience in epifluorescent and confocal microscopy
  • Bonus – experience in cell sorting from rodent brain tissue

What you should know

  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position, and we require that all individuals working in-person be fully vaccinated against COVID-19, including receipt of a vaccine booster shot if recommended by the CDC

How we work together

  • Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
  • Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
  • Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, employer paid basic life insurance,  additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.

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