The CNS In Vivo Manager helps to ensure the smooth operation and cross-project coordination of glial cell transplantation research in Sana's Cambridge CNS lab. More broadly, this multidisciplinary position is intended to dedicate at least 50% effort to bench / wet lab work. Management duties include experimental design and implementation, preclinical transplant coordination, personnel management, coordination of animal husbandry, protocol amendments, and compliance, and assist with inventory and fiscal management within the CNS program.
The wet lab portion of the CNS In Vivo Manager position will support in vivo assessment of human manufactured glial cells transplanted into pre-clinical models. This individual will both manage and help evaluate transplant success into the mouse brain using techniques of murine brain sectioning, fluorescent immunohistochemistry, microscopy, and image analysis within Sana's CNS Cell Therapy lab. This position includes technically diverse bench and analytic work, as well as the training of research staff in techniques and equipment use, across the CNS in vivo program.
The CNS In Vivo Manager will report on a direct basis to the Sr Director, CNS Biology, and work under the broader direction of the Head of CNS Therapy.
As a successful candidate, you are expected to have extensive hands-on expertise in the neurohistological methods necessary to assess transplanted animals, particularly tissue sectioning and immunohistochemistry, quantitative histology and microscopy (epifluorescent and confocal). You should also be familiar with concepts of transgenic mouse husbandry and identification of suitable mouse models. You will have sufficient personal expertise to teach as well as troubleshoot these techniques. Also, you are expected to contribute towards the maintenance of both the histology and surgical lab environments, including day to day operations and personnel coordination, as well as assuring the quality of data collection.
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At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.
Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, employer paid basic life insurance, additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.
We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.
To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.
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