Drug Discovery Project Scientist (In-Vivo)

With over 35 nationalities and a range of backgrounds represented in our Benevolent team, we aim to build an inclusive environment where our people can bring their authentic selves to work, be respected for who they are and the exceptional work they do. We welcome and actively encourage applications from all sections of society and are committed to offering equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, marital, domestic or civil partnership status, sexual orientation, gender identity, parental status, disability, age, citizenship, or any other basis. We see our diversity as an asset as we tackle challenging problems that bridge the gap between drug discovery and technology.

The Role

BenevolentAI is seeking an in-vivo drug discovery scientist to join our newly formed in-vivo project representative team where you will apply your experience as an in vivo pharmacologist and project representative to help drive our diverse portfolio to achieve key milestones. Reporting into the in-vivo project representative team leader and as a core member of a dynamic, multi-disciplinary team of scientists passionate about developing medicines, you will be the responsible in-vivo pharmacology project representative on multiple projects. Working collaboratively with project drug discovery project teams, including DMPK, chemistry, in-vivo and in-vitro colleagues, using your theoretical and practical expertise, you’ll take a hands-on approach to scoping, designing, implementing and interpreting in-vivo pharmacodynamic studies across the portfolio. You will supplement the analysis of results through histology, molecular and biochemical profiling. You will identify and build strong relationships with the best CROs to deliver the appropriate support for projects, build systems and deliver datasets that will have direct impact on project progression

Primary Responsibilities:

• Within the project team, serve as a scientific expert contributing at a high level across in-vivo pharmacology activities, including supporting PKPD, translational efficacy models, TE and biomarker strategy, study design, implementation and interpretation.
• Developing a deep understanding of disease mechanism and target biology, participating in broader project strategy and decision making.
• With a comprehensive understanding of all aspects of study design and implementation, you will be responsible for establishing strong cross functional relationships with key stakeholders within the project core teams, resulting in cohesion and clarity in the delivery of studies and the presentation of decision making data.
• Where required, coordinating in vivo studies in multiple projects across the portfolio to ensure high quality, efficiency and timely delivery of studies whether external or internal.
• You will also have the opportunity to work with other in vivo project reps to support target identification disease deployments.

Additional Responsibilities:

• Current Personal Home Office Licence holder (modules 1-4/A-C, with Module 5 being desirable) is useful but not essential
• Experience writing reports and documentation to support regulatory filing is useful but not essential
• An in-depth understanding of therapy areas such as neuroscience, oncology, and immunology, and in addition drug safety etc would be valuable would be useful but not essential

We are looking for someone with:

• PhD or Degree qualified with experience of working in a vivarium and on in-vivo research activities in drug discovery
• Experience working as a functional representative on project teams, ideally to preclinical development stage but not essential
• Experience of working closely with DMPK and biology leads within project environments, and ideally with a good understanding of drug delivery and PK in relation to PD
• A good understanding of integrated physiology, pathophysiology and in vivo practice and procedures. Experience in designing, directing and implementing in vivo experiments to respond to key research and pharmacodynamic questions in at least two different therapeutic areas
• An in-depth understanding of at least two diverse disease areas
• Evidence of scientific contributions to data-driven decisions that significantly influence project strategy and/or the achievement of key project milestones
• Experience of working with external KOL and/or CROs desirable.
• Excellent communication skills
• Previous Personal Home Office Licence holder (modules 1-4/A-C))

About us

BenevolentAI (AMS: BAI) is a leading, clinical-stage AI-enabled drug discovery and development company listed on the Euronext Amsterdam stock exchange. Through the combined capabilities of its AI platform, scientific expertise, and wet-lab facilities, BenevolentAI is well-positioned to deliver novel drug candidates with a higher probability of clinical success than those developed using traditional methods. The Benevolent Platform™ powers a growing in-house pipeline of 13 named drug programmes and over 10 exploratory programmes, and it maintains successful collaborations with AstraZeneca, as well as leading research and charitable institutions. BenevolentAI is headquartered in London, with a research facility in Cambridge (UK) and a further office in New York.

We share a passion for being part of a mission that matters, and we are always looking for curious and collaborative people who share our values and want to be part of our journey. If that sounds like a fit for you, hit the ‘apply’ button and join us.

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