Director, Global Supply and S&OP Lead

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Leads the end-to-end S&OP process and supply planning integration to balance demand, supply, capacity, and inventory trade-offs through structured decision forums. Owns constraints management, scenario-based decision support, and allocation recommendations where supply is limited. Ensures S&OP decisions translate into executable supply plans with clear owners, timelines, and adherence monitoring. Maintains governance artifacts (assumptions, decisions, actions, metrics) and improves S&OP effectiveness over time. Partners with Manufacturing, Quality, and Commercial to resolve escalations and protect supply and launch timelines.

Key Responsibilities

S&OP Cadence & Decision Forums

• Operate S&OP governance (agenda, pre-reads, decisions, action tracking) and maintain governance artifacts and decision logs
• Ensure follow-through and closure of actions, monitor execution adherence and escalate gaps
• Produce deliverables such as S&OP calendars, pre-read templates, decision logs, and action trackers

Constraints, Scenarios & Allocation

• Own constraints management and scenario planning, quantify impacts and trade-offs
• Develop allocation and prioritization recommendations aligned to service and strategic priorities
• Produce deliverables such as constraint dashboards, scenario packs, and allocation recommendation memos

Planning-to-Execution Translation

• Translate S&OP decisions into executable supply plans and monitor plan adherence through execution handoffs
• Coordinate escalations and recovery actions across manufacturing, logistics, and quality constraints
• Produce deliverables such as execution handoff packs and adherence / performance reports

Required Qualifications

• BS+ (Supply Chain, Engineering, Business, or related)
• 12–15 years supply planning and / or S&OP ownership with executive forum leadership experience
• Demonstrated experience managing constrained supply and driving cross-functional decisions

Preferred Qualifications

• Experience with IBP / S&OP systems and analytics / scenario tooling
• Experience in pharmaceutical / biotech supply chains (preferred)

Key Competencies

• S&OP facilitation, decision governance, and action tracking, pre-read discipline, decision logs, and follow-through
• Constraint management, scenario planning, and allocation governance, trade-off communication (service, inventory, capacity)
• Cross-functional leadership, escalation, and executive-ready risk / decision communication
• Launch / readiness planning inputs, cutover governance alignment, and stabilization support (as applicable)
• Performance management routines, KPI tracking, and continuous improvement of planning effectiveness

We are committed to fostering an inclusive and diverse workplace and do not discriminate on the basis of any legally protected characteristics. Madrigal processes your personal data in connection with its recruitment and talent sourcing activities in accordance with applicable data protection laws. Further information about how your personal data is processed, together with details of your rights and how to exercise them, is available in our Job Applicant Privacy Notice, which is made available to you if you apply through Workday.

Please note that this job description is not exhaustive and may evolve over time. Only shortlisted candidates will be contacted. Applicants must be authorized to work in the country of employment at the time of application. Employment terms, where applicable, will be governed by relevant collective bargaining agreements.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.