Research Associate/Senior Research Associate, In Vivo Pharmacology

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

We are seeking a highly-motivated In Vivo Pharmacology Senior Research Associate  who thrives in a fast-paced and creative environment to push the capabilities of our multiplexed in vivo drug discovery platform. Together with senior researchers, you will play a critical role in executing in vivo studies to support internal research projects. This is a hands-on role and you should have extensive experience in multiple aspects of in vivo pharmacology including dosing, necropsy, perfusion, tissue collection and  sample processing, among others. The ideal candidate must be able to work effectively both in a collaborative setting and independently. 

Responsibilities

• Conduct in vivo mouse studies, including dosing via IV, IP, SQ, and other routes as needed.
• Perform necropsy, tissue dissection, perfusion, and blood/tissue collection (in-life and terminal
• Perform blood collections via submandibular cheek bleeds and cardiac punctures.
• Prepare and process tissues for downstream analysis.
• Accurately label samples, track collection, and maintain comprehensive records.
• Follow protocols rigorously and contribute to protocol refinement when needed.
• Ability to follow SOPs and work independently in a high-throughput setting.
• Maintain accurate and organized data entry and analysis.
• Collaborate with cross-functional teams in a dynamic research environment.
• Strong attention to detail with excellent data organization and recordkeeping.
• Assist in maintaining inventories.

Required Qualifications

• Bachelors or Masters and 1-2+ years of experience (biotech/pharma industry preferred) in executing in vivo pharmacology experiments in mice
• Demonstrated expertise executing hands-on in vivo studies
• Collaborative, curious, and flexible with strong communication skills, both written and oral
• Self-motivated, highly organized,  able to work independently with minimal supervision, and able to multitask
• Strong attention to detail
• A genuine passion for science and developing medicines

Preferred Qualifications

• Familiarity with histology, microscopy, or tissue sectioning
• Experience in bioanalytical assays for protein therapeutics (PCR, nucleic acid extraction, ELISA, Western Blot, etc)
• Skilled with common data analysis and productivity software such as Microsoft Office, GraphPad Prism, and ImageJ.
• Experience  writing detailed research project plans and methodological SOPs that guide yours and other team members’ laboratory activities
• Experience in mouse health monitoring is highly preferred

Base Salary Range: $70,000-108,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.