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Scientist/ Senior Scientist - Translational Cardiac Biology

California, U.S.
Full-Time
On-site
$120,000 – $180,000 per year
This job is no longer available and isn't accepting applications.

TLDR

Advance high-throughput cardiac biology toward organ-scale cryopreservation by developing predictive 2D/3D models and translating cryoprotectant formulations.

Until is a moonshot company building a “pause button” for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we’re laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.

To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.

We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.

About the Role

We are seeking a Scientist/Senior Scientist, Translational Cardiac Biology to join our team. You will be part of a multidisciplinary team that designs, builds, and characterizes new technologies that form the foundation of organ-scale reversible cryopreservation. 

In this role, you will advance cryopreservation formulations by designing, executing, and analyzing high throughput experiments focused on cardiac biology and toxicology. You will establish novel approaches to characterize toxicity and permeability of new cryoprotectant solutions using cardiac cells (hiPSC-CMs, immortalized cells) and advanced 3D in vitro cardiac models. Your work will pioneer the use of predictive 2D and 3D models for toxicity assessment, helping enable human-sized organ preservation and bridging patients to future cures.

Key Responsibilities

  • Develop clinically translatable healthy in vitro models using primary/immortalized cardiac cells, including iPSC-derived cardiomyocytes
  • Design and implement high throughput screening (HTS) experiments to characterize the viability and functional performance of cardiac cells using MEA, calcium imaging, impedance-based readouts
  • Create and validate complex in vitro 3D cardiac models (e.g., organoids, engineered heart tissues, micro-tissues) to accurately assess cardiotoxicity and permeability of new cryoprotectant solutions
  • Develop innovative approaches to characterize cardiotoxicity of new compounds and their interactions with healthy heart function, including functional endpoints such as contractility, electrophysiology, and calcium handling
  • Apply plate-reader, flow cytometry based and/or genomics techniques such as GWAS, RNAseq, and FISH to inform and refine molecular discovery and in vitro models
  • Collaborate closely with cross-functional teams to translate experimental findings into new cryoprotectant solutions for human-sized organ preservation
  • Recruit and mentor team members and take on greater responsibility for experimental design and strategy as needed

    • Who You Are

  • PhD and/or Postdoc training in Cardiac Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, Pharmacology, Toxicology or a related field, or have an equivalent (4+ years) of industry experience leading research projects end-to-end
  • Have a track record of scientific excellence and autonomy, with the ability to independently develop and carry out complex experiments in cardiac biology or a related therapeutic area
  • Hands-on expertise in cell-based assay development, including experience with primary cells, iPSC-derived cell types, or 3D in vitro models
  • Proven ability to design and execute high throughput screening workflows and analyze multiparametric datasets
  • Bring a collaborative mindset and value diverse perspectives
  • Thrive fast-paced environments with high sense of mission and urgency

    • Nice to have

  • Experience evaluating pharmacokinetics and pharmacodynamics, with the ability to apply these frameworks to cryoprotectant formulation development
  • Experience with cardiac electrophysiology, contractility measurement, or calcium imaging techniques
  • Publication record in peer-reviewed journals in cardiac biology, cryobiology, toxicology, or related fields

    • Benefits

  • Opportunity for outsized impact creating the future as an early team member
  • Generous medical, dental, and vision insurance coverage for employees and their dependents
  • Flexible time off and paid holidays
  • Competitive compensation package, including salary and equity
  • Access to a 401(k) retirement savings plan
  • FSA and commuter benefits
  • Subsidized lunch daily

    • As an equal opportunity employer, Until is committed to providing employment opportunities to all individuals. All applicants for positions at Until will be treated without regard to race, color, ethnicity, religion, sex, gender, gender identity and expression, sexual orientation, national origin, disability, age, marital status, veteran status, pregnancy, or any other basis prohibited by applicable law.

    Benefits

    Equity Compensation

    Competitive compensation package, including salary and equity

    subsidized lunch

    Subsidized lunch daily

    Health Insurance

    Generous medical, dental, and vision insurance coverage for employees and their dependents

    FSA and commuter benefits

    Paid Time Off

    Flexible time off and paid holidays

    Until
    Until

    Until is innovating in the field of biology with a focus on organ-scale reversible cryopreservation. We aim to preserve donated organs at subzero temperatures without ice formation, enabling them to be safely rewarming for transplant, while also working towards the larger goal of allowing patients to wait for future cures without losing the possibility of treatment. Our approach combines interdisciplinary expertise to forge solutions that could redefine the boundaries of medicine and organ transplant logistics.

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